Traditionally, the fruit has been used for diabetes, halitosis, hemorrhoids, tumours, tuberculosis, high blood pressure and as a tonic for overall health and energy. The leaves have been ingested in remedies for arthritis, digestive problems, parasites, and dysentery. Topically, the leaves, fruit, and roots are used in poultices for arthritis and joint pain, for headaches, burns and lesions, poisonous bites and to diminish signs of aging.

Noni is used by some cancer patients for its anti-cancer and tumor-reducing possibilities. Some sufferers from immune-compromised diseases such as AIDS and chronic fatigue syndrome use noni to boost the function of the immune system.

People with diabetes and hypoglycemia have reported that noni helps stabilise blood sugar levels. Suffers of arthritis, joint pain, and inflammatory conditions have used noni. Other uses include as a sedative, painkiller, sleeping aid, removal of intestinal parasites, cleansing the digestive tract and improving digestion, and for weight control. It is used as a general health tonic to improve energy, build up resistance and to slow the effects of aging. Noni is also used for asthma; for digestive disorders including ulcers; irritable bowel syndrome; constipation and diarrhea, as well as fibromyalgia, a condition characterised by fatigue and chronic pain.